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Hello, According to ASUS the drive installed in the ASUS TUF FA506IV Laptop, this drive should plug into the M.2 slot built into the laptop. However, the XPG GAMMIX S50 Lite is a Gen4 SSD and the slot in the ASUS TUF FA506IV Laptop is a Gen3 slot and there is a possibility of it reading it, but not reaching its maximum advertised speeds due to the gap in architecture between both drives. Regards, ADATA Team
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