A:Answer As you can tell from the photos, Alienware adopted a very modular design. Access to the internals couldn't be easier, it's incredibly simple.
The Alienware Service channel on YouTube is also helpful, though many of their videos are older models, not this R9 specifically.
The Fan noise issue I had was resolved via BIOS update end of October.
I spoke with Alienware / Dell Tech support yesterday in support of another commenter installing the Corasir H60 AIO water-cooled fan in place of stock air cooler, and learned that not all fans are replaceable, for example, the front ancillary fan (at least not easily)
I hope this helps.