A:Answer No, you don’t need to have a line of sight for the remote to work correctly.
This remote is made to work via a Bluetooth transmission. Meaning as long as you are within a certain range of the device itself the signal will reach.
If you’re one for a neat and tidy, more concealed setup, I’d recommend the “TotalMount” hookup that hides the AppleTV behind your TV. The remote will still work 100%, and you’ll get a cleaner looking setup.