A:Answer It should work "plug & play" style with any PC that has a USB-C port. I hooked it up to my Lenovo Legion 5 through the single USB-C port, and was immediately recognized as a second monitor.
It also has a mini HDMI port, and with an HDMI-to-Mini HDMI adapter cable, and a USB 3.0 charger, you can hook this into literally any computer that has an HDMI output as a second display.
It will work through a USB 3.0 port (there's an included adapter), but it will need a driver from Asus to display through that hookup.
Whichever way you hook it to your computer, the monitor has to be hooked into USB 3.0 / USB-C because it pulls its power from the USB plug, and only ports designed for that version will supply sufficient voltage.