A:Answer Yes, It will. I found that trying to run it in the back paper feed as suggested & or recommended did not work out well, the 110 lb kept jamming, as well as the 80 lb although the 80 lb I purchased was a semi -gloss. I tried all the paper settings, and had been able to get just a few 110 to work in the rear feed, I then realized that when I ran the photo paper which is also a heavier stock and glossy, I used tray 2, not the back feed. So I loaded 110 lb in tray 2 and left the setting at plain paper, and it worked perfect for single sided. I was hesitant to try to duplex the 110 card stock in tray 2, so I just run the one side then do a manual duplex, where I put the printed side face up since it flips it when it feeds. So your answer to the 60 and 80 lb stock, yes, for letter, legal and below sizes. I ran 80 and 110 both in tray 2 without any jamming whatsoever. I have not tried the 80 or 110 lb in the 11x17" size yet, I am going to assume you will need to fight with all the heavier stock in the back feed regardless of size, it just jams too much. Regular weight - 20lb feeds just fine in the back feed.