A:Answer Hexagon, I found out that the answer is actually NO. Just the two slots are running. You have to go into the BIOS and change a bunch of stuff for the four slots to work. I did attempt at putting in four 16GB G.Skill sticks, and it would only register two working. So I now have 2 X 32GB sticks on the way. 16 might be enough for you, but not for myself.