A:Answer The mouse works plug-and-play with Mac OSX (at least with default controls), and the Logitech software allows you to customize all of the buttons, although it does not have some of the Mac-specific touchpad controls available by default (for example, show Launchpad). You could probably work around this by setting up a custom macro in the Logitech software, assuming you've also set up the keyboard shortcut for the command in OSX first.
