A:Answer It will "work" in only the most limited terms. I used this mobo for a Ryzen 9 3950X and a Big Navi GPU with 32 Gb Corsair Vengeance RGB Pro Ddr4, Corsair 140mm RGB Pro Fans, Corsair Liquid CPU cooler, Intel 660 1 TB nvme ssd, Western Digital Caviar 1tb ssd hd all inside a custom vertical hang GPU case and I was lucky if the PC turned on. Second I replaced the mobo with a Asus ROG Strix E Gaming Mobo my build was finally working without a hitch.