A:Answer Yes. the Nikon AF-S DX NIKKOR 18-300mm f/3.5-6.3G ED VR Telephoto Zoom lens is completely compatible with the Nikon D850 FX-format DSLR camera, however, because it is a DX-format lens you will experience a 1.5 crop in images when using it with the D850, which has an FX-format sensor. The AF-S 18-300mm is a versatile, lightweight lens that is ideal for wide-angle landscapes and group photos, beautiful bokeh portraits and extreme close-ups. It's an all-in-one, must-have lens for any growing camera bag.