A:AnswerYes. That should work. You didn’t mention what Ryzen gen chip you have. So I can’t tell you if it’s overkill or not enough GPU. As far as booking up. You should be fine.
A:AnswerAs long as you have an available PCIe x16 slot it should. It is a double-wide card so it takes up to "slots" in the back of the case. Be sure you have enough clearance from the back of the case to the back of the card and you should be good.