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Yes, the SanDisk® Extreme Compact Flash 64GB Memory Card will work in the Nikon D300 camera as it supports the Compact Flash Memory Cards.
Sorry, there was a problem. Please try again later.It is compatible with the D300S , so, I don't see any reason that a D300 won't be very happy with this card. The card is likely capable of transfer speeds beyond the capability of the camera, but, at least you will know that your camera is saving your rapid repeating shots at it's highest possible speed. I use these in my D3, D4 and D5 as well. Nikon cameras like these modules ...
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