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Hello, the difference between the Winix 5300-2 and 5500-2 is mainly the filtration. The Winix 5300-2 comes with 4 carbon filter sheets that need to be replaced every 3 months and the 5500-2 comes with an advanced odor control filter that we recommend washing every 3 months. Both units are equipped with a true HEPA filter and pre-filter!
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