A:Answer My motherboard uses ddr3, and I installed this last weekend with no issues. The question I would have expected with if your mobo is old enough to use ddr3, then you probably have pcie 2 or 2.1 and this card is pcie 3. But that was no issue either since pcie spec is supposed to be backward compatible. Running smooth on my Asus Sabertooth 990fx v1 mobo (pcie 2.0), Corsair 750w psu, 16Gb Mushkin ddr3. But do note that this card is quite LARGE.
Also, make sure your have the 8 or 6+2 connector from your psu to power this bad boy up, as this card won't work without it.