A:Answer It should...every graphics card I've tested as worked fine, including Pascal and Maxwell cards (GTX970 & GTX1080). Generally speaking, there is usually only an issue with newer graphics cards on older hardware (think around Sandy/Ivy Bridge Intel processors).
While I doubt it would be needed for a 1660, you can force the PCI-E 16x slot to Gen 3 in BIOS. It is defaulted to Auto, but a setting of PCI Gen 4 could cause some issues if you are using a riser cable (which is a problem I ran into with my 5700XT).