A:Answer Considering External SSD's are connected to PC's via USB C, and the MSI GS66 having a USB C, I wouldn't see why not. Personally I would rather just purchase a PCIE SSD to place into the second storage slot next to the WIFI card. To do this, take out all the screws on the bottom of the device with a PH00 screwdriver (may be PH000 but can't remember). Locate the second storage bay which will look like a small black rectangle with a bunch if gold pins on the inside. Move to the right of it and unscrew the black screw straight ahead. Then place the SSD in the slot at round a 45 degree angle making sure the notch on the SSD matches the notch in the port, push down and then place the screw over the end of the SSD, keeping it in place.