A:Answer I ended up taking a risk and purchased this mouse. Sure enough, EVERY button (including the blue Windows button) is programmable with Microsoft's Mouse and Keyboard Center software. I don't understand why Microsoft doesn't mention this on their site - it's a HUGE bonus! I use my extra mouse buttons to copy/paste. In fact, I almost use my customized buttons more than the standard-issue left/right buttons. Plus this mouse gives me 4 additional buttons to program (well, two are swipe "buttons").